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21st Virginia Volunteer Cavalry Regiment
Flag of Virginia, 1861
Active August 1862 – April 1865
Country Confederacy
Allegiance Confederate States of America Confederate States of America
Role Cavalry
Engagements American Civil War: Valley Campaigns of 1864
Disbanded April 1865

The 21st Virginia Volunteer Cavalry Regiment was a cavalry regiment raised in Virginia for service in the Confederate States Army during the American Civil War. It fought in Southwest Virginia, East Tennessee, and the Shenandoah Valley.

Virginia's 21st Cavalry Regiment was organized in August, 1862, with companies which had served in the Virginia State Line. The unit was assigned to W.E. Jones' and McCausland's Brigade, and in April, 1864, it contained 317 effectives. It took an active part in various conflicts in East Tennessee, western Virginia, and in the Shenandoah Valley. During mid-April, 1865, the regiment disbanded. Its field officers were Colonel W.E. Peters, Lieutenant Colonel David Edmundson, and Major Stephen P. Halsey.